The novel research carried out at Tel Aviv University demonstrated that some environmental conditions might lead to the structural alterations in myelin sheaths at the time of multiple sclerosis (MS) onset. Myelin sheaths can be described as the “insulating tape” covering axons, which are responsible for carrying electrical impulses in neurons.
The latest study revealed that myelin sheaths undergo structural transitions when they are activated by changes in the regional environmental conditions, such as temperature and salt concentration (salinity). According to the latest study, these transitions make the body susceptible to autoimmune attacks that might lead to MS. Prof. Roy Beck, TAU’s School of Physics and Astronomy, is the lead author of this research, which is available online in the Proceedings of the National Academy of Sciences of the USA. The research uncovers that alterations in the myelin sheaths structure are a key factor in the growth of MS.
On a similar note, the latest research published in the journal Nature offers a novel understanding on how drugs work to repair damaged brain cells that are responsible for causing disability in MS patients. This study was led by scientists at Case Western Reserve University School of Medicine. It proposes novel drug targets & strong early-stage drug candidates that might lead to regenerative drugs for patients with MS and other debilitating neurological disorders.
MS is a progressive and chronic disease that has affected millions of people globally. It is characterized by damage to the protective sheath surrounding nerve cells. If this insulating layer called myelin is absent, nerve cells from the brain and spinal cord tend to struggle for transmitting the electrical impulses. This results in patients with MS to suffer progressive loss of motor skills, balance, and vision. The new research describes how drugs can work to reload myelin demolished by MS.